Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic β-Cells

Endoplasmic reticulum (ER) stress is a key pathogenic factor in type 1 and 2 diabetes. Glycogen synthase kinase 3 (Gsk-3) contributes to β-cell loss in mice. However, the mechanism by which Gsk-3 leads β-cell death remains unclear. ER stress was pharmacologically induced in mouse primary islets and...

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Detalles Bibliográficos
Autores principales: Nagao, Yuko, Amo-Shiinoki, Kikuko, Nakabayashi, Hiroko, Hatanaka, Masayuki, Kondo, Manabu, Matsunaga, Kimie, Emoto, Masahiro, Okuya, Shigeru, Tanizawa, Yukio, Tanabe, Katsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657557/
https://www.ncbi.nlm.nih.gov/pubmed/36362372
http://dx.doi.org/10.3390/ijms232113586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657557/
https://www.ncbi.nlm.nih.gov/pubmed/36362372
http://dx.doi.org/10.3390/ijms232113586

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