Aberrant DNA and RNA Methylation Occur in Spinal Cord and Skeletal Muscle of Human SOD1 Mouse Models of ALS and in Human ALS: Targeting DNA Methylation Is Therapeutic

Amyotrophic lateral sclerosis (ALS) is a fatal disease. Skeletal muscles and motor neurons (MNs) degenerate. ALS is a complex disease involving many genes in multiple tissues, the environment, cellular metabolism, and lifestyles. We hypothesized that epigenetic anomalies in DNA and RNA occur in ALS...

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Detalles Bibliográficos
Autores principales: Martin, Lee J., Adams, Danya A., Niedzwiecki, Mark V., Wong, Margaret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657572/
https://www.ncbi.nlm.nih.gov/pubmed/36359844
http://dx.doi.org/10.3390/cells11213448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657572/
https://www.ncbi.nlm.nih.gov/pubmed/36359844
http://dx.doi.org/10.3390/cells11213448

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