MGL S3 Chimeric Enzyme Drives Apoptotic Death of EGFR-Dependent Cancer Cells through ERK Downregulation

Methionine dependence of malignant cells is one of the cancer hallmarks. It is well described that methionine deprivation drives cancer cells death, both in vitro and in vivo. Methionine gamma-lyase (MGL) isolated from different species or obtained by genetic engineering can be used for effective me...

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Detalles Bibliográficos
Autores principales: Bondarev, Nikolay, Ivanenko, Karina, Khabusheva, Elmira, Lebedev, Timofey, Manukhov, Ilya, Prassolov, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657631/
https://www.ncbi.nlm.nih.gov/pubmed/36361596
http://dx.doi.org/10.3390/ijms232112807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657631/
https://www.ncbi.nlm.nih.gov/pubmed/36361596
http://dx.doi.org/10.3390/ijms232112807

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