Novel BH4-BCL-2 Domain Antagonists Induce BCL-2-Mediated Apoptosis in Triple-Negative Breast Cancer

SIMPLE SUMMARY: Our work has led to the identification of three novel BH4 mimetics, SM216, SM396, and SM949, with nanomolar activities both in vitro and in vivo assays. SM396 binds covalently to the BH4 domain of BCL-2 while the compounds SM216 and SM949 are non-covalent BH4 binders. Our results ill...

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Detalles Bibliográficos
Autores principales: Kanakaveti, Vishnupriya, Ramasamy, Sakthivel, Kanumuri, Rahul, Balasubramanian, Vaishnavi, Saravanan, Roshni, Ezhil, Inemai, Pitani, Ravishankar, Venkatraman, Ganesh, Rayala, Suresh Kumar, Gromiha, M. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657696/
https://www.ncbi.nlm.nih.gov/pubmed/36358660
http://dx.doi.org/10.3390/cancers14215241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657696/
https://www.ncbi.nlm.nih.gov/pubmed/36358660
http://dx.doi.org/10.3390/cancers14215241

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