Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H(+)-ATPase Disassembly—Rescue by Specific Amino Acid Supplementation

The heart is metabolically flexible. Under physiological conditions, it mainly uses lipids and glucose as energy substrates. In uncontrolled diabetes, the heart switches towards predominant lipid utilization, which over time is detrimental to cardiac function. Additionally, diabetes is accompanied b...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Shujin, Neumann, Dietbert, Westenbrink, B. Daan, Schianchi, Francesco, Wong, Li-Yen, Sun, Aomin, Strzelecka, Agnieszka, Glatz, Jan F. C., Luiken, Joost J. F. P., Nabben, Miranda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657709/
https://www.ncbi.nlm.nih.gov/pubmed/36361698
http://dx.doi.org/10.3390/ijms232112909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657709/
https://www.ncbi.nlm.nih.gov/pubmed/36361698
http://dx.doi.org/10.3390/ijms232112909

Ejemplares similares