Cargando…

Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H(+)-ATPase Disassembly—Rescue by Specific Amino Acid Supplementation

The heart is metabolically flexible. Under physiological conditions, it mainly uses lipids and glucose as energy substrates. In uncontrolled diabetes, the heart switches towards predominant lipid utilization, which over time is detrimental to cardiac function. Additionally, diabetes is accompanied b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Shujin, Neumann, Dietbert, Westenbrink, B. Daan, Schianchi, Francesco, Wong, Li-Yen, Sun, Aomin, Strzelecka, Agnieszka, Glatz, Jan F. C., Luiken, Joost J. F. P., Nabben, Miranda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657709/ https://www.ncbi.nlm.nih.gov/pubmed/36361698 http://dx.doi.org/10.3390/ijms232112909

Ejemplares similares

Augmenting Vacuolar H(+)-ATPase Function Prevents Cardiomyocytes from Lipid-Overload Induced Dysfunction
por: Wang, Shujin, et al.
Publicado: (2020)

Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis
por: Wang, Shujin, et al.
Publicado: (2021)

Endosomal v-ATPase as a Sensor Determining Myocardial Substrate Preference
por: Wang, Shujin, et al.
Publicado: (2022)

Putative Role of Protein Palmitoylation in Cardiac Lipid-Induced Insulin Resistance
por: Schianchi, Francesco, et al.
Publicado: (2020)

Metabolic Interventions to Prevent Hypertrophy-Induced Alterations in Contractile Properties In Vitro
por: Geraets, Ilvy M. E., et al.
Publicado: (2021)

Acute and Chronic Effects of Protein Kinase-D Signaling on Cardiac Energy Metabolism
por: Simsek Papur, Ozlenen, et al.
Publicado: (2018)

Phosphatidylinositol 4-kinase IIIβ mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes
por: Sun, A., et al.
Publicado: (2020)

Assessing fatty acid oxidation flux in rodent cardiomyocyte models
por: Rech, M., et al.
Publicado: (2018)

CD36 (SR-B2) as a Target to Treat Lipid Overload-Induced Cardiac Dysfunction
por: Glatz, Jan F.C., et al.
Publicado: (2020)

CD36 (SR-B2) as master regulator of cellular fatty acid homeostasis
por: Glatz, Jan F.C., et al.
Publicado: (2022)

Fluorescent labelling of membrane fatty acid transporter CD36 (SR-B2) in the extracellular loop
por: Liu, Yilin, et al.
Publicado: (2019)

Microbial-Driven Butyrate Regulates Jejunal Homeostasis in Piglets During the Weaning Stage
por: Zhong, Xi, et al.
Publicado: (2019)

Role of the vacuolar ATPase in the Alphavirus replication cycle
por: Schuchman, Ryan M., et al.
Publicado: (2018)

Pharmacological Inhibition of the Vacuolar ATPase in Bloodstream-Form Trypanosoma brucei Rescues Genetic Knockdown of Mitochondrial Gene Expression
por: Schaffner-Barbero, Claudia, et al.
Publicado: (2018)

Flexibility within the Rotor and Stators of the Vacuolar H(+)-ATPase
por: Song, Chun Feng, et al.
Publicado: (2013)

Rotating with the brakes on and other unresolved features of the vacuolar ATPase
por: Rawson, Shaun, et al.
Publicado: (2016)

The curious case of vacuolar ATPase: regulation of signaling pathways
por: Pamarthy, Sahithi, et al.
Publicado: (2018)

SGLT2 Inhibitors and Ketone Metabolism in Heart Failure
por: Saucedo-Orozco, Huitzilihuitl, et al.
Publicado: (2022)

Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy
por: Hayek, Summer R., et al.
Publicado: (2014)

Re-balancing cellular energy substrate metabolism to mend the failing heart(☆)
por: Glatz, Jan F.C., et al.
Publicado: (2019)

An isoform of the vacuolar (H(+))-ATPase accessory subunit Ac45
por: Jansen, Eric J. R., et al.
Publicado: (2009)

The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma
por: Di Cristofori, Andrea, et al.
Publicado: (2015)

Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases
por: Mazhab-Jafari, Mohammad T., et al.
Publicado: (2016)

Vacuolar-type ATPase: A proton pump to lysosomal trafficking
por: FUTAI, Masamitsu, et al.
Publicado: (2019)

RNA Interference of Genes Encoding the Vacuolar-ATPase in Liriomyza trifolii
por: Chang, Ya-Wen, et al.
Publicado: (2021)

Purification of active human vacuolar H(+)-ATPase in native lipid-containing nanodiscs
por: Oot, Rebecca A., et al.
Publicado: (2021)

The vacuolar-ATPase (V-ATPase) modulates matrix metalloproteinase (MMP) isoforms in human pancreatic cancer
por: Chung, Chuhan, et al.
Publicado: (2011)

Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes
por: Steinbusch, Laura K. M., et al.
Publicado: (2011)

Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins
Publicado: (1989)

Mutations in the Proteolipid Subunits of the Vacuolar H(+)-ATPase Provide Resistance to Indolotryptoline Natural Products
por: Chang, Fang-Yuan, et al.
Publicado: (2014)

Probing Subunit-Subunit Interactions in the Yeast Vacuolar ATPase by Peptide Arrays
por: Parsons, Lee S., et al.
Publicado: (2012)

Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H(+))-ATPase Inhibitors †
por: Patil, Renukadevi, et al.
Publicado: (2017)

Vacuolar H(+)-ATPase is not restricted to clear cells of the epididymal epithelium in cattle
por: Kim, Sung Woo, et al.
Publicado: (2021)

The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake
por: Alder, Arne, et al.
Publicado: (2023)

Fractalkine Depresses Cardiomyocyte Contractility
por: Taube, David, et al.
Publicado: (2013)

Mitochondrial therapy for doxorubicin cardiomyopathy: nuclear factor-κB to the rescue?
por: Nijholt, Kirsten Theresa, et al.
Publicado: (2020)

Actomyosin contractility and buckling of microtubules in nucleation, growth and disassembling of focal adhesions
por: Palumbo, S., et al.
Publicado: (2022)

Molecular and functional characterization of vacuolar-ATPase from the American dog tick Dermacentor variabilis
por: Petchampai, N, et al.
Publicado: (2014)

Approaches to High-Throughput Analysis of Cardiomyocyte Contractility
por: Wright, Peter T., et al.
Publicado: (2020)

Reconstitution of Vacuolar-type Rotary H(+)-ATPase/Synthase from Thermus thermophilus
por: Kishikawa, Jun-ichi, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_7cjpfmi4cfv001dnvi7l221h4o