Synthesis and Cytotoxic Activity of 1,2,4-Triazolo-Linked Bis-Indolyl Conjugates as Dual Inhibitors of Tankyrase and PI3K

A series of new 1,2,4-triazolo-linked bis-indolyl conjugates (15a–r) were prepared by multistep synthesis and evaluated for their cytotoxic activity against various human cancer cell lines. It was observed that they were more susceptible to colon and breast cancer cells. Conjugates 15o (IC(50) = 2.0...

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Detalles Bibliográficos
Autores principales: Yakkala, Prasanna A., Panda, Samir R., Shafi, Syed, Naidu, V. G. M., Yar, M. Shahar, Ubanako, Philemon N., Adeyemi, Samson A., Kumar, Pradeep, Choonara, Yahya E., Radchenko, Eugene V., Palyulin, Vladimir A., Kamal, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657870/
https://www.ncbi.nlm.nih.gov/pubmed/36364474
http://dx.doi.org/10.3390/molecules27217642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657870/
https://www.ncbi.nlm.nih.gov/pubmed/36364474
http://dx.doi.org/10.3390/molecules27217642

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