New, Eco-Friendly Method for Synthesis of 3-Chlorophenyl and 1,1′-Biphenyl Piperazinylhexyl Trazodone Analogues with Dual 5-HT(1A)/5-HT(7) Affinity and Its Antidepressant-like Activity

Serotonin 5-HT(1A) and 5-HT(7) receptors play an important role in the pathogenesis and pharmacotherapy of depression. Previously identified N-hexyl trazodone derivatives, 2-(6-(4-(3-chlorophenyl)piperazin-1-yl)hexyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one hydrochloride (7a·HCl), with high affinity...

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Detalles Bibliográficos
Autores principales: Zaręba, Przemysław, Partyka, Anna, Latacz, Gniewomir, Satała, Grzegorz, Zajdel, Paweł, Jaśkowska, Jolanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658223/
https://www.ncbi.nlm.nih.gov/pubmed/36364104
http://dx.doi.org/10.3390/molecules27217270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658223/
https://www.ncbi.nlm.nih.gov/pubmed/36364104
http://dx.doi.org/10.3390/molecules27217270

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