The RSL3 Induction of KLK Lung Adenocarcinoma Cell Ferroptosis by Inhibition of USP11 Activity and the NRF2-GSH Axis

SIMPLE SUMMARY: High NRF2 level confers KLK LUAD cell resistance to ferroptosis. Here, we showed that the inhibition of NRF2-GSH axis sensitized a small molecule RSL3 to induce KLK LUAD cell ferroptosis in vitro. RSL3 treatment inhibited activity of the NRF2-GSH signaling during KLK LUAD cell ferrop...

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Detalles Bibliográficos
Autores principales: Zhang, Wenlong, Li, Xiaohe, Xu, Jiaqian, Wang, Ying, Xing, Zhengcao, Hu, Shuming, Fan, Qiuju, Lu, Shaoyong, Cheng, Jinke, Gu, Jianmin, Cai, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658295/
https://www.ncbi.nlm.nih.gov/pubmed/36358651
http://dx.doi.org/10.3390/cancers14215233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658295/
https://www.ncbi.nlm.nih.gov/pubmed/36358651
http://dx.doi.org/10.3390/cancers14215233

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