Discovery of Mitochondrial Complex I Inhibitors as Anticancer and Radiosensitizer Drugs Based on Compensatory Stimulation of Lactate Release

SIMPLE SUMMARY: To identify inhibitors of mitochondrial respiration as potential anticancer drugs is not an easy matter since cancer cells cultured as monolayers may escape by shifting their metabolic preference toward the use of glycolysis. Here we propose to capitalize on this apparent weakness to...

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Detalles Bibliográficos
Autores principales: Lan, Junjie, Cadassou, Octavia, Corbet, Cyril, Riant, Olivier, Feron, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658316/
https://www.ncbi.nlm.nih.gov/pubmed/36358872
http://dx.doi.org/10.3390/cancers14215454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658316/
https://www.ncbi.nlm.nih.gov/pubmed/36358872
http://dx.doi.org/10.3390/cancers14215454

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