Blockage of KHSRP-NLRP3 by MCC950 Can Reverse the Effect of Manganese-Induced Neuroinflammation in N2a Cells and Rat Brain

Manganese neurotoxicity has been reported to cause a neurodegenerative disease known as parkinsonism. Previous reports have shown that the expression of the KH-type splicing regulatory protein (KHSRP), a nucleic acid-binding protein, and NLRP3 is increased upon Mn exposure. However, the relation bet...

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Detalles Bibliográficos
Autores principales: Singh, Sharad, Shaikh, Ibrahim Ahmed, More, Sunil S., Mahnashi, Mater H., Almohaimeed, Hailah M., El-Sherbiny, Mohamed, Ghoneim, Mohammed M., Umar, Ahmad, Soni, Harshit Kumar, Agrawal, Himanshu, Mannasaheb, Basheer Ahmed, Khan, Aejaz Abdullatif, Muddapur, Uday M., Iqubal, S. M. Shakeel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658363/
https://www.ncbi.nlm.nih.gov/pubmed/36362011
http://dx.doi.org/10.3390/ijms232113224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658363/
https://www.ncbi.nlm.nih.gov/pubmed/36362011
http://dx.doi.org/10.3390/ijms232113224

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