Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles

The rationale to define the biological and molecular parameters derived from structure–activity relationships (SAR) is mandatory for the lead selection of small drug compounds. Several series of small molecules have been synthesized based on a computer-assisted pharmacophore design derived from two...

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Detalles Bibliográficos
Autores principales: Mesangeau, Christophe, Carato, Pascal, Renault, Nicolas, Coevoet, Mathilde, Larchanché, Paul-Emmanuel, Barczyk, Amélie, Buée, Luc, Sergeant, Nicolas, Melnyk, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658513/
https://www.ncbi.nlm.nih.gov/pubmed/36361896
http://dx.doi.org/10.3390/ijms232113111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658513/
https://www.ncbi.nlm.nih.gov/pubmed/36361896
http://dx.doi.org/10.3390/ijms232113111

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