CS12192, a Novel JAK3/JAK1/TBK1 Inhibitor, Synergistically Enhances the Anti-Inflammation Effect of Methotrexate in a Rat Model of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a common disease worldwide and is treated commonly with methotrexate (MTX). CS12192 is a novel JAK3 inhibitor discovered by Chipscreen Biosciences for the treatment of autoimmune diseases. In the present study, we examined the therapeutic effect of CS12192 against RA and...

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Detalles Bibliográficos
Autores principales: Fang, Zhengyu, Hu, Yiping, Dai, Jiajing, He, Lianhua, He, Juan, Xu, Bihua, Han, Xinle, Zhong, Fubo, Lan, Huiyao, Wang, Qingwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658750/
https://www.ncbi.nlm.nih.gov/pubmed/36362183
http://dx.doi.org/10.3390/ijms232113394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658750/
https://www.ncbi.nlm.nih.gov/pubmed/36362183
http://dx.doi.org/10.3390/ijms232113394

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