New Pyrimidine-5-Carbonitriles as COX-2 Inhibitors: Design, Synthesis, Anticancer Screening, Molecular Docking, and In Silico ADME Profile Studies

Two series of cyanopyrimidine hybrids were synthesized bearing either benzo[d]imidazole, benzo[d]oxazole, benzo[d]thiazole, and benzo[b]thiophene derivatives via methylene amino linker 3a–3d (Formula A) or various sulphonamide phenyl moieties 5a–5d (Formula B) at the C-2 position. All compounds’ cyc...

Descripción completa

Detalles Bibliográficos
Autores principales: AL-Ghulikah, Hanan A., El-Sebaey, Samiha A., Bass, Amr K. A., El-Zoghbi, Mona S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658812/
https://www.ncbi.nlm.nih.gov/pubmed/36364312
http://dx.doi.org/10.3390/molecules27217485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658812/
https://www.ncbi.nlm.nih.gov/pubmed/36364312
http://dx.doi.org/10.3390/molecules27217485

Ejemplares similares