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New Pyrimidine-5-Carbonitriles as COX-2 Inhibitors: Design, Synthesis, Anticancer Screening, Molecular Docking, and In Silico ADME Profile Studies

Two series of cyanopyrimidine hybrids were synthesized bearing either benzo[d]imidazole, benzo[d]oxazole, benzo[d]thiazole, and benzo[b]thiophene derivatives via methylene amino linker 3a–3d (Formula A) or various sulphonamide phenyl moieties 5a–5d (Formula B) at the C-2 position. All compounds’ cyc...

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Detalles Bibliográficos
Autores principales:	AL-Ghulikah, Hanan A., El-Sebaey, Samiha A., Bass, Amr K. A., El-Zoghbi, Mona S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658812/ https://www.ncbi.nlm.nih.gov/pubmed/36364312 http://dx.doi.org/10.3390/molecules27217485

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