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Preinitiation Complex Loading onto mRNAs with Long versus Short 5′ TLs

The first step in translation initiation consists in the recruitment of the small ribosome onto the mRNA. This preinitiation complex (PIC) loads via interactions with eIF4F that has assembled on the 5′ cap. It then scans the 5′ TL (transcript leader) to locate a start site. The molecular architectur...

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Detalles Bibliográficos
Autores principales: Weiss, Benjamin, Jaquier-Gubler, Pascale, Curran, Joseph Alphonsus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658832/
https://www.ncbi.nlm.nih.gov/pubmed/36362157
http://dx.doi.org/10.3390/ijms232113369