Acetophenone-Based 3,4-Dihydropyrimidine-2(1H)-Thione as Potential Inhibitor of Tyrosinase and Ribonucleotide Reductase: Facile Synthesis, Crystal Structure, In-Vitro and In-Silico Investigations

The acetophenone-based 3,4-dihydropyrimidine-2(1H)-thione was synthesized by the reaction of 4-methylpent-3-en-2-one (1), 4-acetyl aniline (2) and potassium thiocyanate. The spectroscopic analysis including: FTIR, (1)H-NMR, and single crystal analysis proved the structure of synthesized compound (4)...

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Detalles Bibliográficos
Autores principales: Saeed, Aamer, Ejaz, Syeda Abida, Khalid, Aqsa, Channar, Pervaiz Ali, Aziz, Mubashir, Abbas, Qamar, Wani, Tanveer A., Alsaif, Nawaf A., Alanazi, Mohammed M., Al-Hossaini, Abdullah M., Altwaijry, Nojood, Zargar, Seema, Elhadi, Muawya, Hökelek, Tuncer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658835/
https://www.ncbi.nlm.nih.gov/pubmed/36361953
http://dx.doi.org/10.3390/ijms232113164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658835/
https://www.ncbi.nlm.nih.gov/pubmed/36361953
http://dx.doi.org/10.3390/ijms232113164

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