PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination

PTEN has been implicated in the repair of DNA double-strand breaks (DSBs), particularly through homologous recombination (HR). However, other data fail to demonstrate a direct role of PTEN in DSB repair. Therefore, here, we report experiments designed to further investigate the role of PTEN in DSB r...

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Detalles Bibliográficos
Autores principales: Pei, Xile, Mladenov, Emil, Soni, Aashish, Li, Fanghua, Stuschke, Martin, Iliakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658850/
https://www.ncbi.nlm.nih.gov/pubmed/36361678
http://dx.doi.org/10.3390/ijms232112876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658850/
https://www.ncbi.nlm.nih.gov/pubmed/36361678
http://dx.doi.org/10.3390/ijms232112876

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