Pharmacogenetics of Drug Metabolism: The Role of Gene Polymorphism in the Regulation of Doxorubicin Safety and Efficacy

SIMPLE SUMMARY: The effectiveness and safety of the anti-cancer agent doxorubicin (anthracycline group medicine) depend on the metabolism and retention of the drug in the human organism. Polymorphism of cytochrome p450 (CYP)-encoding genes and detoxifying enzymes such as CYP3A4 and CYP2D6 were found...

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Detalles Bibliográficos
Autores principales: Bagdasaryan, Alina A., Chubarev, Vladimir N., Smolyarchuk, Elena A., Drozdov, Vladimir N., Krasnyuk, Ivan I., Liu, Junqi, Fan, Ruitai, Tse, Edmund, Shikh, Evgenia V., Sukocheva, Olga A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659104/
https://www.ncbi.nlm.nih.gov/pubmed/36358854
http://dx.doi.org/10.3390/cancers14215436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659104/
https://www.ncbi.nlm.nih.gov/pubmed/36358854
http://dx.doi.org/10.3390/cancers14215436

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