Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein—In Silico and In Vitro Evidence

The activity of the P-glycoprotein (P-gp) transporter encoded by the ABCB1 gene confers resistance to anticancer drugs and contributes to cancer-related mortality and morbidity. Recent studies revealed the cytotoxic effects of the endogenous dipeptide carnosine. The current study aimed to investigat...

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Detalles Bibliográficos
Autores principales: Morsy, Mohamed A., Kandeel, Mahmoud, Ibrahim, Ahmed R. N., Abdel-Gaber, Seham A., Jacob, Shery, Venugopala, Katharigatta N., Shinu, Pottathil, El-Daly, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659291/
https://www.ncbi.nlm.nih.gov/pubmed/36364209
http://dx.doi.org/10.3390/molecules27217383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659291/
https://www.ncbi.nlm.nih.gov/pubmed/36364209
http://dx.doi.org/10.3390/molecules27217383

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