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Warmer ambient air temperatures reduce nasal turbinate and brain infection, but increase lung inflammation in the K18-hACE2 mouse model of COVID-19

Warmer climatic conditions have been associated with fewer COVID-19 cases. Herein we infected K18-hACE2 mice housed at the standard animal house temperature of ∼22 °C, or at ∼31 °C, which is considered to be thermoneutral for mice. On day 2 post infection, RNA-Seq analyses showed no significant diff...

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Detalles Bibliográficos
Autores principales: Dumenil, Troy, Le, Thuy T., Rawle, Daniel J., Yan, Kexin, Tang, Bing, Nguyen, Wilson, Bishop, Cameron, Suhrbier, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659553/
https://www.ncbi.nlm.nih.gov/pubmed/36395835
http://dx.doi.org/10.1016/j.scitotenv.2022.160163