Identification and characterization of alternative sites and molecular probes for SARS-CoV-2 target proteins

Three protein targets from SARS-CoV-2, the viral pathogen that causes COVID-19, are studied: the main protease, the 2′-O-RNA methyltransferase, and the nucleocapsid (N) protein. For the main protease, the nucleophilicity of the catalytic cysteine C145 is enabled by coupling to three histidine residu...

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Detalles Bibliográficos
Autores principales: Iyengar, Suhasini M., Barnsley, Kelly K., Vu, Hoang Yen, Bongalonta, Ian Jef A., Herrod, Alyssa S., Scott, Jasmine A., Ondrechen, Mary Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659918/
https://www.ncbi.nlm.nih.gov/pubmed/36385993
http://dx.doi.org/10.3389/fchem.2022.1017394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659918/
https://www.ncbi.nlm.nih.gov/pubmed/36385993
http://dx.doi.org/10.3389/fchem.2022.1017394

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