Tapasin-mediated editing of the MHC I immunopeptidome is epitope specific and dependent on peptide off-rate, abundance, and level of tapasin expression

Tapasin, a component of the major histocompatibility complex (MHC) I peptide loading complex, edits the repertoire of peptides that is presented at the cell surface by MHC I and thereby plays a key role in shaping the hierarchy of CD8+ T-cell responses to tumors and pathogens. We have developed a sy...

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Detalles Bibliográficos
Autores principales: Boulanger, Denise S. M., Douglas, Leon R., Duriez, Patrick J., Kang, Yoyel, Dalchau, Neil, James, Edd, Elliott, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659924/
https://www.ncbi.nlm.nih.gov/pubmed/36389776
http://dx.doi.org/10.3389/fimmu.2022.956603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659924/
https://www.ncbi.nlm.nih.gov/pubmed/36389776
http://dx.doi.org/10.3389/fimmu.2022.956603

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