How osteogenic is dexamethasone?—effect of the corticosteroid on the osteogenesis, extracellular matrix, and secretion of osteoclastogenic factors of jaw periosteum-derived mesenchymal stem/stromal cells

Dexamethasone (dexa) is commonly used to stimulate osteogenic differentiation of mesenchymal stem/stromal cells (MSCs) in vitro. However, it is paradoxical that glucocorticoids (GCs) such as dexa lead to bone loss and increased fracture risk in patients undergoing glucocorticoid therapy, causing glu...

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Detalles Bibliográficos
Autores principales: Umrath, Felix, Pfeifer, Achim, Cen, Wanjing, Danalache, Marina, Reinert, Siegmar, Alexander, Dorothea, Naros, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9660266/
https://www.ncbi.nlm.nih.gov/pubmed/36393863
http://dx.doi.org/10.3389/fcell.2022.953516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9660266/
https://www.ncbi.nlm.nih.gov/pubmed/36393863
http://dx.doi.org/10.3389/fcell.2022.953516

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