Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers

The cardiac KCNQ1 potassium channel carries the important I(Ks) current and controls the heart rhythm. Hundreds of mutations in KCNQ1 can cause life-threatening cardiac arrhythmia. Although KCNQ1 structures have been recently resolved, the structural basis for the dynamic electro-mechanical coupling...

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Detalles Bibliográficos
Autores principales: Ma, Demin, Zhong, Ling, Yan, Zhenzhen, Yao, Jing, Zhang, Yan, Ye, Fan, Huang, Yuan, Lai, Dongwu, Yang, Wei, Hou, Panpan, Guo, Jiangtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661191/
https://www.ncbi.nlm.nih.gov/pubmed/36763058
http://dx.doi.org/10.1073/pnas.2207067119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661191/
https://www.ncbi.nlm.nih.gov/pubmed/36763058
http://dx.doi.org/10.1073/pnas.2207067119

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