Interactive contribution of hyperinsulinemia, hyperglycemia, and mammalian target of rapamycin signaling to valvular interstitial cell differentiation and matrix remodeling

Diabetes and its major key determinants insulin resistance and hyperglycemia are known risk factors for calcific aortic valve disease (CAVD). The processes leading to molecular and structural alterations of the aortic valve are yet not fully understood. In previous studies, we could show that valvul...

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Detalles Bibliográficos
Autores principales: Selig, Jessica I., Krug, H. Viviana, Küppers, Caroline, Ouwens, D. Margriet, Kraft, Felix A., Adler, Elena, Bauer, Sebastian J., Lichtenberg, Artur, Akhyari, Payam, Barth, Mareike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661395/
https://www.ncbi.nlm.nih.gov/pubmed/36386326
http://dx.doi.org/10.3389/fcvm.2022.942430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661395/
https://www.ncbi.nlm.nih.gov/pubmed/36386326
http://dx.doi.org/10.3389/fcvm.2022.942430

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