New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells

[Image: see text] In a continuing search of dual P-gp and hCA XII inhibitors, we synthesized and studied new N,N-bis(alkanol)amine aryl diester derivatives characterized by the presence of a coumarin group. These hybrids contain both P-gp and hCA XII binding groups to synergistically overcome the P-...

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Detalles Bibliográficos
Autores principales: Braconi, Laura, Teodori, Elisabetta, Riganti, Chiara, Coronnello, Marcella, Nocentini, Alessio, Bartolucci, Gianluca, Pallecchi, Marco, Contino, Marialessandra, Manetti, Dina, Romanelli, Maria Novella, Supuran, Claudiu T., Dei, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661477/
https://www.ncbi.nlm.nih.gov/pubmed/36269278
http://dx.doi.org/10.1021/acs.jmedchem.2c01175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661477/
https://www.ncbi.nlm.nih.gov/pubmed/36269278
http://dx.doi.org/10.1021/acs.jmedchem.2c01175

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