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New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells
[Image: see text] In a continuing search of dual P-gp and hCA XII inhibitors, we synthesized and studied new N,N-bis(alkanol)amine aryl diester derivatives characterized by the presence of a coumarin group. These hybrids contain both P-gp and hCA XII binding groups to synergistically overcome the P-...
Autores principales: | Braconi, Laura, Teodori, Elisabetta, Riganti, Chiara, Coronnello, Marcella, Nocentini, Alessio, Bartolucci, Gianluca, Pallecchi, Marco, Contino, Marialessandra, Manetti, Dina, Romanelli, Maria Novella, Supuran, Claudiu T., Dei, Silvia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661477/ https://www.ncbi.nlm.nih.gov/pubmed/36269278 http://dx.doi.org/10.1021/acs.jmedchem.2c01175 |
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