Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization

[Image: see text] The design of multitarget drugs represents a promising strategy in medicinal chemistry and seems particularly suitable for the discovery of anti-inflammatory drugs. Here, we describe the identification of an indoline-based compound inhibiting both 5-lipoxygenase (5-LOX) and soluble...

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Detalles Bibliográficos
Autores principales: Cerqua, Ida, Musella, Simona, Peltner, Lukas Klaus, D’Avino, Danilo, Di Sarno, Veronica, Granato, Elisabetta, Vestuto, Vincenzo, Di Matteo, Rita, Pace, Simona, Ciaglia, Tania, Bilancia, Rossella, Smaldone, Gerardina, Di Matteo, Francesca, Di Micco, Simone, Bifulco, Giuseppe, Pepe, Giacomo, Basilicata, Manuela Giovanna, Rodriquez, Manuela, Gomez-Monterrey, Isabel M., Campiglia, Pietro, Ostacolo, Carmine, Roviezzo, Fiorentina, Werz, Oliver, Rossi, Antonietta, Bertamino, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661480/
https://www.ncbi.nlm.nih.gov/pubmed/36318728
http://dx.doi.org/10.1021/acs.jmedchem.2c00817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661480/
https://www.ncbi.nlm.nih.gov/pubmed/36318728
http://dx.doi.org/10.1021/acs.jmedchem.2c00817

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