Mutation of FMDV L(pro) H138 residue drives viral attenuation in cell culture and in vivo in swine

The foot-and-mouth disease virus (FMDV) leader proteinase (L(pro)) is a papain like protease that cleaves the viral polyprotein and several host factors affecting host cell translation and induction of innate immunity. Introduction of L(pro) mutations ablating catalytic activity is not tolerated by...

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Detalles Bibliográficos
Autores principales: Azzinaro, Paul A., Medina, Gisselle N., Rai, Devendra, Ramirez-Medina, Elizabeth, Spinard, Edward, Rodriguez-Calzada, Monica, Zhu, James, Rieder, Elizabeth, de los Santos, Teresa, Díaz-San Segundo, Fayna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661595/
https://www.ncbi.nlm.nih.gov/pubmed/36387381
http://dx.doi.org/10.3389/fvets.2022.1028077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661595/
https://www.ncbi.nlm.nih.gov/pubmed/36387381
http://dx.doi.org/10.3389/fvets.2022.1028077

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