Design, synthesis, and cytotoxicity evaluation of novel indole-acylhydrazone derivatives of 4-pyridinone as potential histone deacetylase-2 inhibitors

BACKGROUND AND PURPOSE: Histone deacetylation is one of the essential cellular pathways in the growth and spread of cancer, so the design of histone deacetylase (HDAC) inhibitors as anticancer agents is of great importance in pharmaceutical chemistry. Here, a series of indole acylhydrazone derivativ...

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Detalles Bibliográficos
Autores principales: Naghi-Ganji, Niloofar, Saghaei, Lotfollah, Tavakoli, Farial, Azimian, Vajihe, Mirian, Mina, Sirous, Hajar, Rostami, Mahboubeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661679/
https://www.ncbi.nlm.nih.gov/pubmed/36386484
http://dx.doi.org/10.4103/1735-5362.355214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661679/
https://www.ncbi.nlm.nih.gov/pubmed/36386484
http://dx.doi.org/10.4103/1735-5362.355214

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