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Age dependent contribution of entry via the CSF to the overall brain entry of small and large hydrophilic markers
BACKGROUND: Apparent permeability of the blood brain barrier to hydrophilic markers has been shown to be higher in the developing brain. Apart from synthesis in situ, any substance detected in the brain parenchyma can originate from two sources: directly through blood vessels of brain vasculature an...
Autores principales: | Qiu, Fiona, Huang, Yifan, Saunders, Norman R., Habgood, Mark D., Dziegielewska, Katarzyna M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661750/ https://www.ncbi.nlm.nih.gov/pubmed/36376903 http://dx.doi.org/10.1186/s12987-022-00387-z |
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