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MiRNA/mRNA network topology in hepatitis virus B-related liver cirrhosis reveals miR-20a-5p/340-5p as hubs initiating fibrosis

BACKGROUND: The pathophysiology of hepatitis B-related liver cirrhosis (HBV-LC) remains unclear. This study aimed to explore the disease mechanisms using topological analysis of the miRNA/mRNA network. METHODS: Paired miRNA/mRNA sequencing was performed with thirty-three peripheral blood mononuclear...

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Detalles Bibliográficos
Autores principales: Yao, Heng, Li, Peng, Xin, Jiaojiao, Liang, Xi, Jiang, Jing, Shi, Dongyan, Li, Jiang, Hassan, Hozeifa Mohamed, Chen, Xin, Li, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661777/
https://www.ncbi.nlm.nih.gov/pubmed/36376845
http://dx.doi.org/10.1186/s12920-022-01390-x