Systemic Delivery of mPEG‐Masked Trispecific T‐Cell Nanoengagers in Synergy with STING Agonists Overcomes Immunotherapy Resistance in TNBC and Generates a Vaccination Effect

T‐cell engagers (TCEs) represent a breakthrough in hematological malignancy treatment but are vulnerable to antigen escape and lack a vaccination effect. The “immunologically cold” solid tumor presents substantial challenges due to intratumor heterogeneity and an immunosuppressive tumor microenviron...

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Detalles Bibliográficos
Autores principales: Shen, Ming, Chen, Chuanrong, Guo, Qianqian, Wang, Quan, Liao, Jinghan, Wang, Liting, Yu, Jian, Xue, Man, Duan, Yourong, Zhang, Jiali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661824/
https://www.ncbi.nlm.nih.gov/pubmed/36089659
http://dx.doi.org/10.1002/advs.202203523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661824/
https://www.ncbi.nlm.nih.gov/pubmed/36089659
http://dx.doi.org/10.1002/advs.202203523

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