Orally Bioavailable Prodrugs of ψ-GSH: A Potential Treatment for Alzheimer’s Disease

[Image: see text] Addressing glycation-induced oxidative stress in Alzheimer’s disease (AD) is an emerging pharmacotherapeutic strategy. Restoration of the brain glyoxalase enzyme system that neutralizes reactive dicarbonyls is one such approach. Toward this end, we designed, synthesized, and evalua...

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Detalles Bibliográficos
Autores principales: Xie, Wei, Cao, Bin, Zhu, Haizhou, Raza, Abbas, Juckel, Nicholas, Xie, Jiashu, Jiang, Rongrong, Vince, Robert, Lee, Michael K., More, Swati S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662183/
https://www.ncbi.nlm.nih.gov/pubmed/36353871
http://dx.doi.org/10.1021/acs.jmedchem.2c00779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662183/
https://www.ncbi.nlm.nih.gov/pubmed/36353871
http://dx.doi.org/10.1021/acs.jmedchem.2c00779

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