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Orally Bioavailable Prodrugs of ψ-GSH: A Potential Treatment for Alzheimer’s Disease
[Image: see text] Addressing glycation-induced oxidative stress in Alzheimer’s disease (AD) is an emerging pharmacotherapeutic strategy. Restoration of the brain glyoxalase enzyme system that neutralizes reactive dicarbonyls is one such approach. Toward this end, we designed, synthesized, and evalua...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662183/ https://www.ncbi.nlm.nih.gov/pubmed/36353871 http://dx.doi.org/10.1021/acs.jmedchem.2c00779 |