High-throughput mapping of RNA solvent accessibility at the single-nucleotide resolution by RtcB ligation between a fixed 5′-OH-end linker and unique 3′-P-end fragments from hydroxyl radical cleavage

Given the challenges for the experimental determination of RNA tertiary structures, probing solvent accessibility has become increasingly important to gain functional insights. Among various chemical probes developed, backbone-cleaving hydroxyl radical is the only one that can provide unbiased detec...

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Detalles Bibliográficos
Autores principales: Solayman, Md, Litfin, Thomas, Zhou, Yaoqi, Zhan, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662193/
https://www.ncbi.nlm.nih.gov/pubmed/36369947
http://dx.doi.org/10.1080/15476286.2022.2145098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662193/
https://www.ncbi.nlm.nih.gov/pubmed/36369947
http://dx.doi.org/10.1080/15476286.2022.2145098

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