Combined targeting of soluble latent TGF-ß and a solid tumor-associated antigen with adapter CAR T cells

Solid tumors consist of malignant and nonmalignant cells that together create the local tumor microenvironment (TME). Additionally, the TME is characterized by the expression of numerous soluble factors such as TGF-β. TGF-β plays an important role in the TME by suppressing T cell effector function a...

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Detalles Bibliográficos
Autores principales: Werchau, Niels, Kotter, Bettina, Criado-Moronati, Elvira, Gosselink, Andre, Cordes, Nicole, Lock, Dominik, Lennartz, Simon, Kolbe, Carolin, Winter, Nora, Teppert, Karin, Engert, Fabian, Webster, Brian, Mittelstaet, Joerg, Schaefer, Daniel, Mallmann, Peter, Mallmann, Michael R., Ratiu, Dominik, Assenmacher, Mario, Schaser, Thomas, von Bergwelt-Baildon, Michael, Abramowski, Pierre, Kaiser, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662194/
https://www.ncbi.nlm.nih.gov/pubmed/36387056
http://dx.doi.org/10.1080/2162402X.2022.2140534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662194/
https://www.ncbi.nlm.nih.gov/pubmed/36387056
http://dx.doi.org/10.1080/2162402X.2022.2140534

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