A network paradigm predicts drug synergistic effects using downstream protein–protein interactions

In some cases, drug combinations affect adverse outcome phenotypes by binding the same protein; however, drug‐binding proteins are associated through protein–protein interaction (PPI) networks within the cell, suggesting that drug phenotypes may result from long‐range network effects. We first used...

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Detalles Bibliográficos
Autores principales: Wilson, Jennifer L., Steinberg, Ethan, Racz, Rebecca, Altman, Russ B., Shah, Nigam, Grimes, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662203/
https://www.ncbi.nlm.nih.gov/pubmed/36204824
http://dx.doi.org/10.1002/psp4.12861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662203/
https://www.ncbi.nlm.nih.gov/pubmed/36204824
http://dx.doi.org/10.1002/psp4.12861

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