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A network paradigm predicts drug synergistic effects using downstream protein–protein interactions
In some cases, drug combinations affect adverse outcome phenotypes by binding the same protein; however, drug‐binding proteins are associated through protein–protein interaction (PPI) networks within the cell, suggesting that drug phenotypes may result from long‐range network effects. We first used...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662203/ https://www.ncbi.nlm.nih.gov/pubmed/36204824 http://dx.doi.org/10.1002/psp4.12861 |