Enhanced recombinant protein production in CHO cell continuous cultures under growth-inhibiting conditions is associated with an arrested cell cycle in G1/G0 phase

Low temperature and sodium butyrate (NaBu) are two of the most used productivity-enhancing strategies in CHO cell cultures during biopharmaceutical manufacturing. While these two approaches alter the balance in the reciprocal relationship between cell growth and productivity, we do not fully underst...

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Detalles Bibliográficos
Autores principales: Avello, Verónica, Torres, Mauro, Vergara, Mauricio, Berrios, Julio, Valdez-Cruz, Norma A., Acevedo, Cristian, Molina Sampayo, Maria, Dickson, Alan J., Altamirano, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662745/
https://www.ncbi.nlm.nih.gov/pubmed/36374852
http://dx.doi.org/10.1371/journal.pone.0277620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662745/
https://www.ncbi.nlm.nih.gov/pubmed/36374852
http://dx.doi.org/10.1371/journal.pone.0277620

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