Cargando…
Characterization of sequence determinants of enhancer function using natural genetic variation
Sequence variation in enhancers that control cell-type-specific gene transcription contributes significantly to phenotypic variation within human populations. However, it remains difficult to predict precisely the effect of any given sequence variant on enhancer function due to the complexity of DNA...
Autores principales: | Yang, Marty G, Ling, Emi, Cowley, Christopher J, Greenberg, Michael E, Vierbuchen, Thomas |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662815/ https://www.ncbi.nlm.nih.gov/pubmed/36043696 http://dx.doi.org/10.7554/eLife.76500 |
Ejemplares similares
-
Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins
por: Wong, Matthew WK, et al.
Publicado: (2020) -
Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes
por: Hepworth, Jo, et al.
Publicado: (2020) -
Promoter sequence and architecture determine expression variability and confer robustness to genetic variants
por: Einarsson, Hjörleifur, et al.
Publicado: (2022) -
Genetics of trans-regulatory variation in gene expression
por: Albert, Frank Wolfgang, et al.
Publicado: (2018) -
Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes
por: Ward, Michelle C, et al.
Publicado: (2021)