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Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins
A fundamental question in protein science is where allosteric hotspots – residues critical for allosteric signaling – are located, and what properties differentiate them. We carried out deep mutational scanning (DMS) of four homologous bacterial allosteric transcription factors (aTFs) to identify ho...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662819/ https://www.ncbi.nlm.nih.gov/pubmed/36226916 http://dx.doi.org/10.7554/eLife.79932 |