Overproduction of IFNγ by Cbl-b–Deficient CD8(+) T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity

Regulatory T cells (Treg) are an integral component of the adaptive immune system that negatively affect antitumor immunity. Here, we investigated the role of the E3 ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) in establishing CD8(+) T-cell resistance to Treg-mediated suppression to enhance...

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Detalles Bibliográficos
Autores principales: Han, SeongJun, Liu, Zhe Qi, Chung, Douglas C., Paul, Michael St., Garcia-Batres, Carlos R., Sayad, Azin, Elford, Alisha R., Gold, Matthew J., Grimshaw, Natasha, Ohashi, Pamela S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662906/
https://www.ncbi.nlm.nih.gov/pubmed/35181779
http://dx.doi.org/10.1158/2326-6066.CIR-20-0973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662906/
https://www.ncbi.nlm.nih.gov/pubmed/35181779
http://dx.doi.org/10.1158/2326-6066.CIR-20-0973

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