Cargando…

Overproduction of IFNγ by Cbl-b–Deficient CD8(+) T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity

Regulatory T cells (Treg) are an integral component of the adaptive immune system that negatively affect antitumor immunity. Here, we investigated the role of the E3 ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) in establishing CD8(+) T-cell resistance to Treg-mediated suppression to enhance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, SeongJun, Liu, Zhe Qi, Chung, Douglas C., Paul, Michael St., Garcia-Batres, Carlos R., Sayad, Azin, Elford, Alisha R., Gold, Matthew J., Grimshaw, Natasha, Ohashi, Pamela S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662906/ https://www.ncbi.nlm.nih.gov/pubmed/35181779 http://dx.doi.org/10.1158/2326-6066.CIR-20-0973

Ejemplares similares

Overproduction of IL-2 by Cbl-b deficient CD4(+) T cells provides resistance against regulatory T cells
por: Han, SeongJun, et al.
Publicado: (2020)

Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells
por: Iwata, Shigeru, et al.
Publicado: (2020)

Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity
por: Tran, Charles W., et al.
Publicado: (2020)

IFN-γ-Secreting-Mesenchymal Stem Cells Exert an Antitumor Effect In Vivo via the TRAIL Pathway
por: Yang, Xinyuan, et al.
Publicado: (2014)

Guidelines for diagnosis and management of the cobalamin-related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency
por: Huemer, Martina, et al.
Publicado: (2016)

Dual oxidase 1 limits the IFNγ-associated antitumor effect of macrophages
por: Meziani, Lydia, et al.
Publicado: (2020)

Detrimental Effects of IFN-γ on an Epidermolysis Bullosa Simplex Cell Model and Protection by a Humanized Anti–IFN-γ Monoclonal Antibody
por: Badowski, Cedric, et al.
Publicado: (2022)

Correction: Dual oxidase 1 limits the IFNγ-associated antitumor effect of macrophages
Publicado: (2020)

Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells
por: Tong, Haijun, et al.
Publicado: (2021)

Myeloid-Derived Suppressor Cells Specifically Suppress IFN-γ Production and Antitumor Cytotoxic Activity of Vδ2 T Cells
por: Sacchi, Alessandra, et al.
Publicado: (2018)

A novel CBL-B(flox/flox) mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells
por: Goetz, Benjamin, et al.
Publicado: (2016)

IFN-γ Mediates the Rejection of Haematopoietic Stem Cells in IFN-γR1-Deficient Hosts
por: Rottman, Martin, et al.
Publicado: (2008)

IFN-γ modulates Ly-49 receptors on NK cells in IFN-γ-induced pregnancy failure
por: Li, Zhong-Yin, et al.
Publicado: (2015)

CCL3 Enhances Antitumor Immune Priming in the Lymph Node via IFNγ with Dependency on Natural Killer Cells
por: Allen, Frederick, et al.
Publicado: (2017)

Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027
por: Chen, Yihua, et al.
Publicado: (2010)

The IL-10 and IFN-γ pathways are essential to the potent immunosuppressive activity of cultured CD8(+ )NKT-like cells
por: Zhou, Li, et al.
Publicado: (2008)

CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8(+) T cells
por: Hansen, Aida S., et al.
Publicado: (2018)

Cbl-b Positively Regulates Btk-mediated Activation of Phospholipase C-γ2 in B Cells
por: Yasuda, Tomoharu, et al.
Publicado: (2002)

Cancer stem cell immunoediting by IFNγ
por: Galassi, Claudia, et al.
Publicado: (2023)

An Overproduction of Scholars
Publicado: (1893)

The synergistic interaction between the calcineurin B subunit and IFN-γ enhances macrophage antitumor activity
por: Su, Z, et al.
Publicado: (2015)

Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells
Publicado: (1996)

Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing
por: Li, Xin, et al.
Publicado: (2020)

Activation of 4-1BBL(+) B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma
por: Lee-Chang, Catalina, et al.
Publicado: (2020)

USP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity
por: Hong, Bangxing, et al.
Publicado: (2014)

Metabolic engineering of Bacillus amyloliquefaciens for poly-gamma-glutamic acid (γ-PGA) overproduction
por: Feng, Jun, et al.
Publicado: (2014)

Identification of IFN-γ-producing innate B cells
por: Bao, Yan, et al.
Publicado: (2014)

Proteomic investigation of Cbl and Cbl-b in neuroblastoma cell differentiation highlights roles for SHP-2 and CDK16
por: Pedersen, Anna-Kathrine, et al.
Publicado: (2021)

c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1
por: Meyer, Rosana D, et al.
Publicado: (2011)

Inhibition of FGFR Reactivates IFNγ Signaling in Tumor Cells to Enhance the Combined Antitumor Activity of Lenvatinib with Anti-PD-1 Antibodies
por: Adachi, Yusuke, et al.
Publicado: (2022)

Neoantigen Presentation and IFNγ Signaling on the Same Tumor-associated Macrophage are Necessary for CD4 T Cell–mediated Antitumor Activity in Mice
por: Perez-Diez, Ainhoa, et al.
Publicado: (2022)

IFN‐γ–STAT1‐mediated NK2R expression is involved in the induction of antitumor effector CD8 (+) T cells in vivo
por: Shen, Weidong, et al.
Publicado: (2023)

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4(+) CAR T-cell antitumor activity
por: Boulch, Morgane, et al.
Publicado: (2023)

UV mutagenesis for the overproduction of xylanase from Bacillus mojavensis PTCC 1723 and optimization of the production condition
por: Ghazi, Shokoofeh, et al.
Publicado: (2014)

IFNγ-primed periodontal ligament cells regulate T-cell responses via IFNγ-inducible mediators and ICAM-1-mediated direct cell contact
por: Singhatanadgit, Weerachai, et al.
Publicado: (2022)

Cbl Suppresses B Cell Receptor–Mediated Phospholipase C (Plc)-γ2 Activation by Regulating B Cell Linker Protein–Plc-γ2 Binding
por: Yasuda, Tomoharu, et al.
Publicado: (2000)

Peptide-Pulsed Dendritic Cells Have Superior Ability to Induce Immune-Mediated Tissue Destruction Compared to Peptide with Adjuvant
por: Dissanayake, Dilan, et al.
Publicado: (2014)

Damaged mitochondria and overproduction of ROS in Fanconi anemia cells
por: Lyakhovich, Alex
Publicado: (2013)

Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy
por: An, Wei, et al.
Publicado: (2015)

Knockout of c-Cbl/Cbl-b slows c-Met trafficking resulting in enhanced signaling in corneal epithelial cells
por: Tarvestad-Laise, Kate, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_epbbmpjejjtasns40cvi1pveab