Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL

PURPOSE: Cereblon (CRBN), a substrate receptor of the E3 ubiquitin ligase complex CRL4(CRBN), is the target of the small molecules lenalidomide and avadomide. Upon binding of the drugs, Aiolos and Ikaros are recruited to the E3 ligase, ubiquitylated, and subsequently degraded. In diffuse large B-cel...

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Detalles Bibliográficos
Autores principales: Hagner, Patrick R., Chiu, Hsiling, Chopra, Vivek S., Colombo, Martino, Patel, Nisha, Estevez, Maria Ortiz, Waldman, Michelle F., Loos, Remco, Towfic, Fadi, Gandhi, Anita K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662945/
https://www.ncbi.nlm.nih.gov/pubmed/35583604
http://dx.doi.org/10.1158/1078-0432.CCR-21-3347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662945/
https://www.ncbi.nlm.nih.gov/pubmed/35583604
http://dx.doi.org/10.1158/1078-0432.CCR-21-3347

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