SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity

Astrocytes are highly heterogeneous in their phenotype and function, which contributes to CNS disease, repair, and aging; however, the molecular mechanism of their functional states remains largely unknown. Here, we show that activation of sirtuin 1 (SIRT1), a protein deacetylase, played an importan...

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Detalles Bibliográficos
Autores principales: Zhang, Weifeng, Xiao, Dan, Li, Xing, Zhang, Yuan, Rasouli, Javad, Casella, Giacomo, Boehm, Alexandra, Hwang, Daniel, Ishikawa, Larissa L.W., Thome, Rodolfo, Ciric, Bogoljub, Curtis, Mark T., Rostami, Abdolmohamad, Zhang, Guang-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663155/
https://www.ncbi.nlm.nih.gov/pubmed/36136587
http://dx.doi.org/10.1172/JCI151803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663155/
https://www.ncbi.nlm.nih.gov/pubmed/36136587
http://dx.doi.org/10.1172/JCI151803

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