Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase

Enteropeptidase (EP) initiates intestinal digestion by proteolytically processing trypsinogen, generating catalytically active trypsin. EP dysfunction causes a series of pancreatic diseases including acute necrotizing pancreatitis. However, the molecular mechanisms of EP activation and substrate rec...

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Detalles Bibliográficos
Autores principales: Yang, Xiaoli, Ding, Zhanyu, Peng, Lisi, Song, Qiuyue, Zhang, Deyu, Cui, Fang, Xia, Chuanchao, Li, Keliang, Yin, Hua, Li, Shiyu, Li, Zhaoshen, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663175/
https://www.ncbi.nlm.nih.gov/pubmed/36376282
http://dx.doi.org/10.1038/s41467-022-34364-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663175/
https://www.ncbi.nlm.nih.gov/pubmed/36376282
http://dx.doi.org/10.1038/s41467-022-34364-9

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