AAA+ protease-adaptor structures reveal altered conformations and ring specialization

ClpAP, a two-ring AAA+ protease, degrades N-end-rule proteins bound by the ClpS adaptor. Here we present high-resolution cryo-EM structures of Escherichia coli ClpAPS complexes, showing how ClpA pore loops interact with the ClpS N-terminal extension (NTE), which is normally intrinsically disordered....

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Detalles Bibliográficos
Autores principales: Kim, Sora, Fei, Xue, Sauer, Robert T., Baker, Tania A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663308/
https://www.ncbi.nlm.nih.gov/pubmed/36329286
http://dx.doi.org/10.1038/s41594-022-00850-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663308/
https://www.ncbi.nlm.nih.gov/pubmed/36329286
http://dx.doi.org/10.1038/s41594-022-00850-3

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