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3D visualization of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast

The placental syncytiotrophoblast, a syncytium without cell-cell junctions, is the primary barrier between the mother and the fetus. Despite no apparent anatomical pathway for paracellular diffusion of solutes across the syncytiotrophoblast, size-dependent paracellular diffusion is observed. Here we...

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Detalles Bibliográficos
Autores principales: Lewis, Rohan M., Baskaran, Harikesan, Green, Jools, Tashev, Stanimir, Palaiologou, Eleni, Lofthouse, Emma M., Cleal, Jane K., Page, Anton, Chatelet, David S., Goggin, Patricia, Sengers, Bram G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663330/
https://www.ncbi.nlm.nih.gov/pubmed/36387021
http://dx.doi.org/10.1016/j.isci.2022.105453